Focus on HER2 in cancer: Summary

Slide Deck

View the HER2 slide deck

Gene amplification and receptor overexpression can create an excess of HER2 signaling¹
HER2 signaling can lead to multiple effects on cancer cells, including⁵:
- Cell proliferation
- DNA synthesis
- Tumorigenesis
HER2 is the preferred dimerization partner for all HER family receptors²
HER2/HER3 and HER1/HER2 heterodimers are of particular importance in cancer^3,4,6

HER2 has been successfully targeted in breast cancer and is being investigated as a potential therapeutic target in ovarian cancer
Methods of targeting the HER2 receptor under investigation include:
- Prevention of receptor activation by binding to the extracellular domain of the receptor²⁸
- Prevention of HER2 dimerization²⁸
- Inhibiting phosphorylation of the tyrosine kinase domain of the receptor⁴
- Inhibiting HER pathway signaling intermediates⁴

Additional clinical research is necessary to further clarify the relationship between HER2 and cancer.