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• HER3 evaluation

Focus on HER3 testing

Methods of HER3 testing have not been standardized

Unlike HER1/EGFR and HER2, HER3 status is not routinely analyzed in clinical practice. Therefore, there is no standardized method by which HER3 status is assessed. Methods that have been used in clinical trials include:

• Immunohistochemistry (IHC), which measures levels of receptor expression on the cell surface using a receptor-specific antibody¹¹
• Fluorescence in situ hybridization (FISH), which measures the number of copies of the HER3 gene¹²
• Quantitative reverse transcription polymerase chain reaction (RT-PCR), which measures HER3 status by messenger RNA levels¹³

As HER3 continues to be investigated in cancer, standardized methods of assessing HER3 status may need to be developed.

 

Next Section: HER3 in ovarian cancer

References

HER3