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Focus on HER3

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“Although HER TKIs can suppress the EGFR- or HER2-mediated phosphorylation of HER3 and inactivate downstream Akt signalling, HER3 appears to be a resilient node in this circuitry.”—Hsieh AC and Moasser MM, Br J Cancer, 2007¹

HER3 is increasingly coming under investigation for its role in the development of cancer. This section of ResearchHERPathways.com focuses on the way HER3 may cause cancer cells to grow and spread in spite of currently available therapeutic agents, as well as its prognostic value and role in breast and ovarian cancers. Click on the links below to learn more.

In This Section

Dysregulation of HER3 signaling in cancer
Evaluation of HER3 expression
HER3 as a prognostic factor
HER3 effects in ovarian cancer
HER3 effects in breast cancer
HER3 as a potential therapeutic target
Summary
References

Next Section: HER3 dysregulation

References

Research HER Pathways

HER3

HER3 dysregulation
HER3 evaluation
HER3 and prognosis
HER3 in ovarian cancer
HER3 in breast cancer
HER3 as a therapeutic target
Summary
References

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