Focus on HER3 in ovarian cancer

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View the HER3 slide deck

To date, few studies have measured the prevalence of HER3 expression in ovarian cancer.

Source	N	Definition of HER3 overexpression	Percentage of tumors with HER3 overexpression
Tanner et al, J Clin Oncol, 2006²	116	Rajkumar score >8 (note: a Rajkumar score of 8 was the median value in this study)	53%
Rajkumar et al, Clin Mol Pathol, 1996¹¹	98	Higher HER3 expression than in normal ovarian epithelium by IHC	16%

Additional studies are needed to determine the prevalence of HER3 overexpression in ovarian cancer.

Preclinical research suggests the presence of HER3 interactions specific to ovarian cancer. These include⁴:

Prolonged activation of the MAPK survival pathway in response to activation of both HER3 and HER4
Activation by the ligand heregulin independent of HER2 and HER4

The clinical significance of these findings is unclear.