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• HER3
• HER3: Summary

Focus on HER3 in cancer: Summary

HER3 is a key component of HER2-mediated tumorigenesis

• HER3 is a requirement for HER2 signaling in cancer¹
  • HER3 enables HER2 signaling by dimerizing with HER2
• Effects of HER2/HER3 signaling include:
  • Activation of the PI3K signaling pathway¹
  • Escape from HER2 inhibition⁶

HER3 is a negative prognostic factor

• HER3 overexpression has been correlated with:
  • Shorter disease-free survival in breast cancer¹¹
  • Shorter overall survival in ovarian cancer²

HER3 represents a potential therapeutic target

• Methods of targeting could include:
  • Targeting HER2/HER3 dimerization²⁰
  • Targeting HER3 ligands
  • Targeting downstream signaling pathways¹

Additional clinical research is needed to better clarify the role of HER3 in cancer.

 

Next Section: HER3: References

References

HER3